The Calypso ™ automated composition-gradient accessory and software are used in conjunction with a MALS detector (CG-MALS) to characterize biomolecular interactions, label-free and immobilization-free. CG-MALS determines equilibrium dissociation constants self- and hetero-association as well as more complex interactions.

Also useful for automation of Zimm plots, dn/dc analysis, reaction kinetics and polymer interaction analyses.

https://www.wyatt.com/products/instruments/calypso-ii-label-free-biomolecular-interactions.html